Priceline.com

Rank: No. 2
Latest 12-Month Sales: $4.1 billion
Estimated EPS Current Fiscal Year: $23.13
Estimated EPS Next Fiscal Year: $30.29

The online booking site's recent success has been driven by international travel, particularly to emerging market destinations. Priceline shares have the best five-year performance in the S&P 500: a total return of 972 percent from 2007 to 2011.

Photograph by: Daniel Acker/Bloomberg
 
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