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Chairman and CEO, MannKind
AGE: 82
A physics major as the University of California at Los Angeles, Mann founded his first company in aerospace, supplying solar cells and power supplies for spacecraft. He but later moved into the health-care field, founding companies that made pacemakers and insulin pumps. Mann still works 80 hours a week on his various companies, such as MannKind (MNKD:O), which is developing an inhalable form of insulin for diabetics as well as a pharmaceutical regimen for shrinking tumors in ovarian, colorectal, and prostate cancers.