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Missouri

Missouri

Columbia

Population: 89,963
Labor force: 52,094
Startups per 1,000 people: 3.09
Small business per 1,000 people: 42

What to know about starting up in Columbia:
"We moved our company here last June from San Francisco and the Silicon Valley area. We moved here because we wanted to put our company in the smartest, most economically viable place that we could. Smartest means across the street from the University of Missouri Journalism School. Columbia provided a huge cost savings. This would have cost us four to five times more to have built in the Bay Area."
-Jim Spencer, president, online news service Newsy