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1: San Francisco/Silicon Valley

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1: San Francisco/Silicon Valley

Patent Score: 1,056,650.1

Tops by a huge margin and no wonder: The San Francisco Bay Area is high tech's world capital. Apple, Google, Hewlett-Packard, and Intel are just a few of the trailblazing companies based there. The area also boasts a strong biotech sector as well as top-tier research universities and federal labs.