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Nearest city: Louisville
Median family income: $53,636
Runners-up: Louisville, Bowling Green
Owensboro, situated on the southern bank of the Ohio River, 109 miles southwest of Louisville, is an industrial hub with aluminum, coal, steel processors, and natural gas operations. But it's the combination of low crime, outstanding school test scores, and a low cost of living that makes Owensboro a great place to raise kids.